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This specification covers coextruded poly(vinyl chloride) plastic pipe with a cellular core and concentric inner and outer solid layers. The pipe is produced using a multilayer coextrusion die for nonpressure use in three series: an IPS Schedule 40 series; a PS series with an iron pipe size outside diameter with varying wall thickness as required for pipe stiffness of 25, 50, and 100; and a sewer and drain series. The pipe shall comply with the minimum wall thickness, outside diameter, length, stiffness, flattening, impact strength, bond strength, and extrusion quality requirements.1.1 This specification covers coextruded poly(vinyl chloride) (PVC) plastic pipe with a cellular core and concentric inner and outer solid layers, and is produced using a multilayer coextrusion die for nonpressure use in three series: an IPS Schedule 40 series for DWV; a PS series with an iron pipe size (IPS) outside diameter with varying wall thickness as required for pipe stiffnesses of 25, 50, and 100 for communication conduit, and a sewer and drain series.1.2 The function of this specification is to provide standardization of product-technical data and serve as a purchasing guide.1.3 The text of this specification references notes, footnotes, and appendixes which provide explanatory material. The notes and footnotes (excluding those in tables and figures) shall not be considered as requirements of the specification.NOTE 1: All the pipe series covered by this specification are permitted to be perforated or belled for joining by solvent cement or belled for joining by an elastomeric seal (gasket). Because this pipe is OD controlled, the inside diameter will vary, and therefore, the pipe ID is not suitable for use as a socket. (For more information see Specification D2672.)NOTE 2: This standard specifies dimensional, performance and test requirements for plumbing and fluid handling applications, but does not address venting of combustion gases.1.4 The values stated in inch-pound units are to be regarded as standard. The values given in parentheses are mathematical conversions to SI units that are provided for information only and are not considered standard.NOTE 3: Specifications related to this specification are as follows: D2665, D2729, D3034, F512, F758, and F789.1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.1.6 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

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4.1 This practice is to be used to help assess the biocompatibility of materials used in medical devices. It is designed to test the effect of particles released from medical devices and biomaterials on macrophages or other cells.4.2 The appropriateness of the methods should be carefully considered by the user since not all materials or applications need to be tested by this practice.4.3 Abbreviations: 4.3.1 FCS (FBS)—Fetal Calf Serum (Fetal Bovine Serum)4.3.2 FGFs—Fibroblast Growth Factors4.3.3 HBSS—Hank’s Balanced Salt Solution4.3.4 HEPES—A buffering salt (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid)4.3.5 IL17—Interleukin 174.3.6 IL18—Interleukin 184.3.7 IL1β—Interleukin 1 beta4.3.8 IL6—Interleukin 64.3.9 IL8—Interleukin 84.3.10 LAL—Limulus Amebocyte Lysate4.3.11 LPS—lipopolysaccharide (endotoxin)4.3.12 MCP1—Monocyte Chemotactic Protein-14.3.13 MMPs—Matrix Metalloproteinases4.3.14 NO—Nitric Oxide4.3.15 PBS—Phosphate Buffered Saline4.3.16 PGE2—Prostaglandin E24.3.17 RPMI 1640—Specific Growth Medium (Roswell Park Memorial Institute)4.3.18 TGFβ—Transforming growth factor beta4.3.19 TNFα–—Tumor Necrosis Factor alpha4.3.20 VEGF—Vascular Endothelial Growth Factor1.1 This practice covers the assessment of cellular responses to wear particles and degradation products from implanted materials that may lead to a cascade of biological responses resulting in damage to adjacent and remote tissues. In order to ascertain the role of particles in stimulating such responses, the nature of the responses, and the consequences of the responses, established protocols are needed. This is an emerging, rapidly developing area, and the information gained from standard protocols is necessary to interpret cellular responses to particles and to determine if these correlate with in vivo responses. Since there are many possible and established ways of determining responses, a single standard protocol is not stated. However, well described protocols are needed to compare results from different investigators using the same materials and to compare biological responses for evaluating (ranking) different materials. For laboratories without established protocols, recommendations are given and indicated with an asterisk (*).1.2 Since the purpose of the following test procedures is to predict the response in human tissues, the use of human (preferably macrophage lineage) cells is recommended. However, the use of non-macrophage cell lineage or the use of cells from non-human and non-primate sources may be acceptable. The source of the cells or the cell line used should be justified based on the cellular responses under test and/or tissue of interest. Non-human cells should not be used if there is evidence of possible cross-species difference for specific test results as the results of this in vitro test may not correspond to actual human response.1.3 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.1.5 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

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4.1 This test method provides information regarding the behavior of cellular materials under compressive loads. Test data is obtained, and from a complete load-deformation curve it is possible to compute the compressive stress at any load (such as compressive stress at proportional-limit load or compressive strength at maximum load) and to compute the effective modulus of elasticity.4.2 Compression tests provide a standard method of obtaining data for research and development, quality control, acceptance or rejection under specifications, and special purposes. The tests cannot be considered significant for engineering design in applications differing widely from the load - time scale of the standard test. Such applications require additional tests such as impact, creep, and fatigue.4.3 Before proceeding with this test method, reference shall be made to the specification of the material being tested. Any test specimen preparation, conditioning, dimensions, or testing parameters, or a combination thereof, covered in the materials specification shall take precedence over those mentioned in this test method. If there are no material specifications, then the default conditions apply.1.1 This test method describes a procedure for determining the compressive properties of rigid cellular materials, particularly expanded plastics.1.2 The values stated in SI units are to be regarded as the standard. The values in parentheses are for information only.1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.NOTE 1: This test method and ISO 844 are technically equivalent.1.4 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

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4.1 If the material to be tested includes forming skins, the apparent overall density, or the apparent core density, or both, shall be determined. If the material does not have forming skins, the term overall density is not applicable.4.2 This test method is also applicable to spray foam materials.4.3 Before proceeding with this test method, reference shall be made to the specification of the material being tested. Any test specimen preparation, conditioning, dimensions, or testing parameters, or combination thereof, covered in the relevant ASTM materials specification shall take precedence over those mentioned in this test method. If there are no relevant ASTM material specifications, then the default conditions in this method apply.4.4 When density or apparent density is used in reference to a cellular plastic, without further qualification, it shall be interpreted as follows:4.4.1 density—shall be interpreted as being the apparent overall density if the material is to be used with forming skins intact.4.4.2 density—shall be interpreted as the apparent core density if the forming skins have been, or will be, removed before the material is used.1.1 This test method covers the density of a cellular plastic. Density can be evaluated as the apparent overall density (includes forming skins) or by apparent core density (forming skins removed).1.2 The values stated in SI units are to be regarded as standard. The values given in parentheses are mathematical conversions to inch-pound units that are provided for information only and are not considered standard.1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.NOTE 1: This test method is equivalent to ISO 845.1.4 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

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This test method establishes standard procedure for determining the tensile and tensile adhesion properties of rigid cellular plastics in the form of test specimens of standard shape under defined conditions of temperature, humidity, and testing machine speed. Tensile properties shall be measured using any of three types of specimens: Type A shall be the preferred specimen in those cases where enough sample material exists to form the necessary specimen; Type B shall be the preferred specimen when only smaller specimens are available, as in sandwich panels, etc.; Type C shall be the preferred specimen for the determination of tensile adhesive properties of a cellular plastic to a substrate as in a sandwich panel or the bonding strength of a cellular plastic to a single substrate. This test method requires the use of the following apparatuses: a constant-rate-of-crosshead-movement type testing machine; self-aligning type grips for holding test specimens; an extension indicator; and a lathe specimen cutter.1.1 This test method covers the determination of the tensile and tensile adhesion properties of rigid cellular materials in the form of test specimens of standard shape under defined conditions of temperature, humidity, and testing machine speed.1.2 Tensile properties shall be measured using any of three types of specimens:1.2.1 Type A shall be the preferred specimen in those cases where enough sample material exists to form the necessary specimen.1.2.2 Type B shall be the preferred specimen when only smaller specimens are available, as in sandwich panels, etc.1.2.3 Type C shall be the preferred specimen for the determination of tensile adhesive properties of a cellular plastic to a substrate as in a sandwich panel (top and bottom substrate) or the bonding strength of a cellular plastic to a single substrate.1.3 The values stated in SI units are to be regarded as standard. The values given in parentheses are mathematical conversions to inch-pound units that are provided for information only and are not considered standard.NOTE 1: There is no known ISO equivalent to this test method.1.4 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

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